L-Dopa induces under-damped visually guided motor responses in Parkinson's disease
Identifieur interne : 001C97 ( Main/Exploration ); précédent : 001C96; suivant : 001C98L-Dopa induces under-damped visually guided motor responses in Parkinson's disease
Auteurs : Wing-Lok Au [Singapour] ; NI LEI [Canada] ; Meeko M. K. Oishi [Canada] ; Martin J. Mckeown [Canada]Source :
- Experimental brain research [ 0014-4819 ] ; 2010.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
Abstract
Parkinson's disease preferentially affects internally generated movements, e.g., movements recalled from memory, while externally cued movements are relatively preserved. However, L-dopa may have effects on visually guided movements as well as error-related processing. Fourteen Parkinson's disease (PD) subjects (on and off L-dopa medication) as well as ten normal controls performed a tracking task using a joystick. During discrete 30 s blocks, the visual feedback of the actual tracking errors were attenuated, amplified or unaltered. Second order dynamical system models, with the desired trajectory as the input and the actual motor performance as the output, were used to characterize the motor performance by the each subject under each condition. Although the overall root-mean-square tracking error did not significantly differ between groups, the nature of the motor performance differed significantly across groups. A clear dissociation was made between manipulations of error feedback-which altered the natural frequency of the models-and the effects of L-dopa, which affected damping. Compared to normal controls, PD subjects were significantly over-damped before medication and underdamped after medication. We interpret our results as being suggestive of L-dopa normalization of compensatory overactive cerebellar activity in PD.
Affiliations:
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K." last="Oishi">Meeko M. K. Oishi</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Electrical and Computer Engineering, University of British Columbia</s1><s2>Vancouver</s2><s3>CAN</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Vancouver</wicri:noRegion></affiliation></author><author><name sortKey="Mckeown, Martin J" sort="Mckeown, Martin J" uniqKey="Mckeown M" first="Martin J." last="Mckeown">Martin J. Mckeown</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Electrical and Computer Engineering, University of British Columbia</s1><s2>Vancouver</s2><s3>CAN</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Vancouver</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Medicine (Neurology), University of British Columbia</s1><s2>Vancouver</s2><s3>CAN</s3><sZ>4 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Vancouver</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Brain Research Centre, University of British Columbia</s1><s2>Vancouver</s2><s3>CAN</s3><sZ>4 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Vancouver</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Experimental brain research</title><title level="j" type="abbreviated">Exp. brain res.</title><idno type="ISSN">0014-4819</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Experimental brain research</title><title level="j" type="abbreviated">Exp. brain res.</title><idno type="ISSN">0014-4819</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cerebellum</term><term>Human</term><term>Memory</term><term>Parkinson disease</term><term>Tracking task</term><term>Trajectory</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Mémoire</term><term>Tâche poursuite</term><term>Trajectoire</term><term>Cervelet</term><term>Maladie de Parkinson</term><term>Homme</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Parkinson's disease preferentially affects internally generated movements, e.g., movements recalled from memory, while externally cued movements are relatively preserved. However, L-dopa may have effects on visually guided movements as well as error-related processing. Fourteen Parkinson's disease (PD) subjects (on and off L-dopa medication) as well as ten normal controls performed a tracking task using a joystick. During discrete 30 s blocks, the visual feedback of the actual tracking errors were attenuated, amplified or unaltered. Second order dynamical system models, with the desired trajectory as the input and the actual motor performance as the output, were used to characterize the motor performance by the each subject under each condition. Although the overall root-mean-square tracking error did not significantly differ between groups, the nature of the motor performance differed significantly across groups. A clear dissociation was made between manipulations of error feedback-which altered the natural frequency of the models-and the effects of L-dopa, which affected damping. Compared to normal controls, PD subjects were significantly over-damped before medication and underdamped after medication. We interpret our results as being suggestive of L-dopa normalization of compensatory overactive cerebellar activity in PD.</div></front></TEI><affiliations><list><country><li>Canada</li><li>Singapour</li></country></list><tree><country name="Singapour"><noRegion><name sortKey="Au, Wing Lok" sort="Au, Wing Lok" uniqKey="Au W" first="Wing-Lok" last="Au">Wing-Lok Au</name></noRegion></country><country name="Canada"><noRegion><name sortKey="Ni Lei" sort="Ni Lei" uniqKey="Ni Lei" last="Ni Lei">NI LEI</name></noRegion><name sortKey="Mckeown, Martin J" sort="Mckeown, Martin J" uniqKey="Mckeown M" first="Martin J." last="Mckeown">Martin J. Mckeown</name><name sortKey="Mckeown, Martin J" sort="Mckeown, Martin J" uniqKey="Mckeown M" first="Martin J." last="Mckeown">Martin J. Mckeown</name><name sortKey="Mckeown, Martin J" sort="Mckeown, Martin J" uniqKey="Mckeown M" first="Martin J." last="Mckeown">Martin J. Mckeown</name><name sortKey="Oishi, Meeko M K" sort="Oishi, Meeko M K" uniqKey="Oishi M" first="Meeko M. K." last="Oishi">Meeko M. K. Oishi</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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